Question 1

In cardiac glycoside, position of ?- unsaturated lactone ring is&#10;A)C - 3&#10;B)C - 14&#10;C)C - 17&#10;D)C - 23

Accepted Answer

Cardiac glycosides have a characteristic structural feature which is a ?-unsaturated lactone ring attached at the C-17 position on the steroid nucleus.

Question 2

Activity of cardiac glycoside depends to a great extent on&#10;A)23rd carbonyl oxygen&#10;B)C - 3 OH&#10;C)Side chain at C - 14&#10;D)Side chain at C - 17

Accepted Answer

23rd carbonyl oxygen&#10;

Question 3

Angiotensin II causes rise in blood pressure by:&#10;A)Direct vasoconstriction&#10;B)Releasing adrenaline from adrenal medulla&#10;C)Increasing central sympathetic tone&#10;D)All of the above

Accepted Answer

Angiotensin II causes a rise in blood pressure through multiple mechanisms: it directly causes vasoconstriction, stimulates the release of adrenaline from the adrenal medulla, and increases central sympathetic tone, all of which contribute to increased blood pressure.

Question 4

Digitalis slows the heart in congestive heart failure by:&#10;A)Increasing vagal tone&#10;B)Decreasing sympathetic overactivity&#10;C)Direct depression of sinoatrial node&#10;D)All of the above

Accepted Answer

Digitalis has a multifaceted mechanism of action in the treatment of congestive heart failure. It increases vagal tone, which can slow the heart rate by affecting the parasympathetic nervous system. It also decreases sympathetic overactivity, which is beneficial because excessive sympathetic stimulation can exacerbate heart failure by increasing the heart rate and force of contraction, leading to further deterioration of cardiac function. Additionally, Digitalis directly depresses the sinoatrial node, which can help to reduce heart rate. Therefore, all of the listed mechanisms contribute to the ability of Digitalis to slow the heart in congestive heart failure.

Question 5

Methyldopa is&#10;A)Parasympathomimetic&#10;B)Parasympatholytic&#10;C)Sympathomimetic&#10;D)Sympatholytic

Accepted Answer

Methyldopa is classified as a sympatholytic drug because it lowers blood pressure by inhibiting sympathetic nervous system activity. It does this indirectly by being converted into methylnorepinephrine, which then acts as a false neurotransmitter, reducing overall sympathetic outflow.

Question 6

Losartan is&#10;A)Renin release blocker&#10;B)ACE inhibitor&#10;C)Angiotension I blocker&#10;D)Angiotension II blocker

Accepted Answer

The answer of Losartan is&#10;A)Renin release blocker&#10;B)ACE inhibitor&#10;C)Angiotension I blocker&#10;D)Angiotension...

Question 7

IUPAC name of Dobutamine is&#10;A)4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol&#10;B)4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}methyl)benzene-1,2-diol&#10;C)4-(2-{[4-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)benzene-1,2-diol&#10;D)4-(2-{[4-(4-hydroxyphenyl) propan -2-yl]amino}methyl)benzene-1,2-diol

Accepted Answer

The correct IUPAC name for Dobutamine is 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol, which matches choice A. This name accurately describes the chemical structure of Dobutamine, including the presence of a 4-hydroxyphenyl group attached to a butan-2-yl chain, which is further connected through an amino linkage to an ethyl group attached to a benzene ring with two hydroxyl groups at the 1 and 2 positions.

Question 8

1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol is IUPAC name of&#10;A)Atenolol&#10;B)Metoprolol&#10;C)Captopril&#10;D)Hydralazine

Accepted Answer

The IUPAC name given corresponds to Metoprolol, which is a beta-blocker used to treat high blood pressure and angina.

Question 9

Hydralazine is synthesized from&#10;A)2-formyl benzoic acid and Hydrazine&#10;B)Methacrylic acid&#10;C)2-azidoethanol&#10;D)o-nitro toluene

Accepted Answer

Hydralazine is synthesized from 2-formyl benzoic acid and hydrazine, through a process that involves the formation of a hydrazone intermediate, which is then hydrogenated to produce hydralazine.

Question 10

The principal action common to all class I antiarrhythmic drugs is: A)Na⁺ channel blockade B)K⁺ channel opening C)Depression of impulse conduction D)Prolongation of effective refractory period

Accepted Answer

Class I antiarrhythmic drugs primarily work by blocking sodium channels, which affects the depolarization phase of the cardiac action potential.

Question 11

Identify high ceiling diuretic.&#10;A)Chlorthiazide&#10;B)Furosemide&#10;C)Spironolactone&#10;D)Amiloride

Accepted Answer

The answer of Identify high ceiling diuretic.&#10;A)Chlorthiazide&#10;B)Furosemide&#10;C)Spironolactone&#10;D)Amiloride...

Question 12

_____________ is carboxylic acid moiety containing.&#10;A)Captopril&#10;B)Enalapril&#10;C)Fosinopril&#10;D)Bepridil

Accepted Answer

The answer of _____________ is carboxylic acid moiety containing.&#10;A)Captopril&#10;B)Enalapril&#10;C)Fosinopril&#10;D)Bepridil...

Question 13

Given structure is of&#10;A)Captopril&#10;B)Enalapril&#10;C)Fosinopril&#10;D)Bepridil

Accepted Answer

The answer of Given structure is of&#10;A)Captopril&#10;B)Enalapril&#10;C)Fosinopril&#10;D)Bepridil...

Question 14

_____________ is sulfhydryl moiety containing.&#10;A)Captopril&#10;B)Enalapril&#10;C)Fosinopril&#10;D)Bepridil

Accepted Answer

The answer of _____________ is sulfhydryl moiety containing.&#10;A)Captopril&#10;B)Enalapril&#10;C)Fosinopril&#10;D)Bepridil...

Question 15

Given drug is A)? blocker B)? blocker C)K⁺ channel blocker D)Ca++ channel blocker

Accepted Answer

The answer of Given drug is A)? blocker B)? blocker C)K⁺ channel blocker D)Ca++...

Question 16

The antiarrhythmic drug which decreases both rate of depolarization (phase 0) as well as rate of repolarization (phase 3) of myocardial fibres is:&#10;A)Lignocaine&#10;B)Propranolol&#10;C)Quinidine&#10;D)Verapamil

Accepted Answer

The answer of The antiarrhythmic drug which decreases both rate...

Question 17

The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack:&#10;A)Isosorbide dinitrate&#10;B)Pentaerythritol tetranitrate&#10;C)Diltiazem&#10;D)Dipyridamole

Accepted Answer

The answer of The following drug is used to reduce...

Question 18

Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate:&#10;A)Coronary&#10;B)Cutaneous&#10;C)Renal&#10;D)Cranial

Accepted Answer

The answer of Blood flow in the following vascular bed...

Question 19

Phase II in cardiac action potential is&#10;A)Fast depolarization&#10;B)Partial repolarization&#10;C)Plateau&#10;D)Repolarization

Accepted Answer

The answer of Phase II in cardiac action potential is&#10;A)Fast...

Question 20

In HMG-CoA-Reductase Inhibitors, Lactone ring may be substituted at&#10;A)C- 15&#10;B)C- 16&#10;C)C-17&#10;D)C -18

Accepted Answer

The answer of In HMG-CoA-Reductase Inhibitors, Lactone ring may be...

Question 21

2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of&#10;A)Flecainide&#10;B)Atenolol&#10;C)Verapamil&#10;D)Lignocaine

Accepted Answer

The answer of 2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of&#10;A)Flecainide&#10;B)Atenolol&#10;C)Verapamil&#10;D)Lignocaine...

Question 22

Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:&#10;A)Glyceryl trinitrate&#10;B)Isosorbide dinitrate&#10;C)Isosorbide mononitrate&#10;D)Erythrityl tetranitrate

Accepted Answer

The answer of Select the organic nitrate which undergoes minimal...

Question 23

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:&#10;A)Increase in total coronary blood flow&#10;B)Redistribution of coronary blood flow&#10;C)Reduction of cardiac preload&#10;D)Reduction of cardiac afterload

Accepted Answer

The answer of The primary mechanism of beneficial effect of...

Question 24

Organic nitrates relax vascular smooth muscle by:&#10;A)Increasing intracellular cyclic GMP&#10;B)Increasing intracellular cyclic AMP&#10;C)Decreasing intracellular cyclic AMP&#10;D)Both 'A' and 'C' are correct

Accepted Answer

The answer of Organic nitrates relax vascular smooth muscle by:&#10;A)Increasing...

Question 25

Nitrate tolerance is least likely to develop with the use of:&#10;A)Sustained release oral glyceryl trinitrate&#10;B)Sublingual glyceryl trinitrate&#10;C)Transdermal glyceryl trinitrate&#10;D)Oral pentaerythritol tetranitrate

Accepted Answer

The answer of Nitrate tolerance is least likely to develop...

Deck 1: Cardiovascular Drugs