Deck 1: Methods of Calculation for Individualized Drug Dosing

Question 1

Order: cyclophosphamide 500 mg/m² in 500 mL of normal saline solution (NSS) over 90 minutes Patient height and weight: 5 ft 10 in, 142 lb Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20 mg/mL
a. What is the patient's body surface area (BSA) (m²)?
b. What is the total dose?
c. How many milliliters should you prepare?

Answer 1

a.
b. 500 mg/m² *1.78 m² = 890 mg
c. FE: 890 mg/100 mg * 5 mL = 44.5 mL
OR

Question 2

Order: cisplatin 50 mg/m² in 500 mL of NSS intravenously over 90 minutes Patient height and weight: 5 ft 6 in, 160 lb Drug available: cisplatin 100 mg/100 mL
a. What is the patient's BSA (m²)?
b. What is the total dose?
c. How many milliliters should you prepare?

Answer 2

a.
b. 50 mg *1.84 m² = 92 mg
c. FE: 92 mg/100 mg* 100 mL = 92 mL
OR

Question 3

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give dacarbazine 250 mg/m²/day * 5 days. Patient height: 5 ft 10 in , Patient weight: 173 lb What is the daily dose with
a. square root method?
b. nomogram?

Answer 3

a.
250 mg/m²/day * 1.97 m² = 493 mg/day
b. Height 70 in, weight 173 lb, intersects 2.02 m²
250 mg/m²/day * 2.02 m² = 505 $\approx$ 500 mg/day

Question 4

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give 5-fluorouracil 450 mg/m²/wk. Patient height: 5 ft 6 in , Patient weight: 210 lb What is the weekly dose with
a. square root method?
b. nomogram?

Question 5

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give leucovorin 200 mg/m²/wk. Patient height: 5 ft 6 in , Patient weight: 210 lb What is the weekly dose with
a. square root method?
b. nomogram?

Question 6

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give cisplatin 30 mg/m²/day *3 days. Patient height: 70 in , Patient weight: 80 kg What is the daily dose with
a. square root method?
b. nomogram?

Question 7

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give cisplatinum 80 mg/m²/wk. Patient height: 6 ft 2 in , Patient weight: 186 lb What is the weekly dose with
a. square root method?
b. nomogram?

Question 8

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give etoposide 120 mg/m²/wk. Patient height: 74 in , Patient weight: 70 kg What is the weekly dose with
a. square root method?
b. nomogram?

Question 9

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give Cytoxan 600 mg/m²/wk. Patient height: 70 in , Patient weight: 85 kg What is the weekly dose with
a. square root method?
b. nomogram?

Question 10

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give Adriamycin 60 mg/m²/wk. Patient height: 70 in , Patient weight: 80 kg What is the weekly dose with
a. square root method?
b. nomogram?

Question 11

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give vincristine 2 mg/m²/week. Patient height: 62 in , Patient weight: 75 kg What is the weekly dose with
a. square root method?
b. nomogram?

Question 12

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give mitomycin 15 mg/m²/week. Patient height: 65 in , Patient weight: 64 kg What is the weekly dose with
a. square root method?
b. nomogram?

Question 13

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give mitoxantrone 12 mg/m²/day*3 days. Patient height: 5 ft 8 in , Patient weight: 150 lb What is the daily dose with
a. square root method?
b. nomogram?

Question 14

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give cytosine arabinoside 100 mg/m²/day * 7 days. Patient height: 5 ft 2 in , Patient weight: 130 lb What is the weekly dose with
a. square root method?
b. nomogram?

Question 15

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give methotrexate 3.3 mg/m²/day *7 days. Patient height: 72 in , Patient weight: 82 kg What is the daily dose with
a. square root method?
b. nomogram?

Question 16

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give prednisone 60 mg/m²/day * 7 days. Patient height: 72 in , Patient weight: 84 kg What is the daily dose with
a. square root method?
b. nomogram?

Question 17

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give idarubicin hydrochloride 12 mg/m²/day * 3 days. Patient height: 60 in , Patient weight: 60 kg What is the daily dose with
a. square root method?
b. nomogram?

Question 18

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give cytarabine 100 mg/m²/day * 7 days. Patient height: 64 in , Patient weight: 65 kg What is the daily dose with
a. square root method?
b. nomogram?

Question 19

Order: streptozocin 1000 mg/m² in 100 mL D₅W over 2 hours Patient's height and weight: 5 ft 2 in and 210 lb Drug available: streptozocin 1 g powdered vial, reconstitute with 9.5 mL NS; yields 100 mg/mL
a. What is the patient's BSA (m²)?
b. What is the total dose?
c. How many milliliters should you prepare?

Question 20

Order: methotrexate 3 mg/m² PO * 2 weekly Patient's height and weight: 5 ft 2 in and 130 lb Drug available: methotrexate tablets 2.5, 5, 7.5 mg
a. What is the patient's BSA (m²)?
b. What is the total dose?

Question 21

Order: sargramostim 250 mcg/m²/day, dilute in 50 mL and infuse over 2 hours Patient's height and weight: 5 ft 10 in and 285 lb Drug available: sargramostim 500 mcg/mL
a. What is the patient's BSA (m²)?
b. What is the total dose?
c. How many milliliters should you prepare?

Question 22

Order: clofarabine 52 mg/m² daily and infuse in 250 mL D₅W over 2 hours Patient's height and weight: 5 ft 4 in and 115 lb Drug available: 20 mg/20 mL
a. What is the patient's BSA (m²)?
b. What is the total dose?
c. How many milliliters should you prepare?