Question 1

Order: cyclophosphamide 500 mg/m² in 500 mL of normal saline solution (NSS) over 90 minutes Patient height and weight: 5 ft 10 in, 142 lb Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20 mg/mL a. What is the patient's body surface area (BSA) (m²)? b. What is the total dose? c. How many milliliters should you prepare?

Accepted Answer

a. b. 500 mg/m² *1.78 m² = 890 mg c. FE: 890 mg/100 mg * 5 mL = 44.5 mL OR

Question 2

Order: cisplatin 50 mg/m² in 500 mL of NSS intravenously over 90 minutes Patient height and weight: 5 ft 6 in, 160 lb Drug available: cisplatin 100 mg/100 mL a. What is the patient's BSA (m²)? b. What is the total dose? c. How many milliliters should you prepare?

Accepted Answer

a. b. 50 mg *1.84 m² = 92 mg c. FE: 92 mg/100 mg* 100 mL = 92 mL OR

Question 3

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give dacarbazine 250 mg/m²/day * 5 days. Patient height: 5 ft 10 in , Patient weight: 173 lb What is the daily dose with a. square root method? b. nomogram?

Accepted Answer

a. 250 mg/m²/day * 1.97 m² = 493 mg/day b. Height 70 in, weight 173 lb, intersects 2.02 m² 250 mg/m²/day * 2.02 m² = 505 $\approx$ 500 mg/day

Question 4

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. Give 5-fluorouracil 450 mg/m²/wk. Patient height: 5 ft 6 in , Patient weight: 210 lb What is the weekly dose with a. square root method? b. nomogram?

Accepted Answer