Deck 27: Treatment of Irritable Bowel Syndrome,ulcerative Colitis and Crohns Disease

Question 1

Ulcerative colitis produces inflammation in the upper layers of the lining of the _____ and colon,whereas Crohn's disease produces inflammation deep in the _____.

A)small intestine,intestinal wall
B)large intestine,stomach wall
C)colon,intestinal wall
D)small intestine,colon

Answer 1

A
Ulcerative colitis produces inflammation in the upper layers of the lining of the small intestine and colon,whereas Crohn's disease produces inflammation deep in the intestinal wall.

Question 2

Azathioprine,6-mercaptopurine,and methotrexate are classified as antimetabolites.They are used in the treatment of Crohn's disease to ______.

A)reduce inflammation
B)control diarrhea
C)induce remission
D)enhance the immune system

Answer 2

C
Azathioprine,6-mercaptopurine,and methotrexate are classified as antimetabolites.They are used in the treatment of Crohn's disease to induce remission.

Question 3

Aminosalicylates work via what mechanism?

A)stimulating evacuation of the bowel
B)bacteria in the colon metabolize the drugs and release the active metabolite (5-ASA)
C)reducing inflammation
D)b and c

Answer 3

D
Sulfasalazine (sulfapyridine + 5-ASA)and olsalazine (two 5-ASA molecules)are prodrugs.Bacteria in the colon metabolize the drugs and release the active metabolite (5-ASA).Mesalamine and mesalazine are coated with a pH-dependent resin.The 5-ASA is released in the pH of the distal ileum (mesalamine)and proximal ileum (mesalazine)rather than the colon.

Question 4

How are the patients who have irritable bowel syndrome,ulcerative colitis,or Crohn's disease tested to confirm diagnosis?

A)sigmoidoscopy
B)proctoscopy
C)colonoscopy
D)jejunoscopy

Question 5

Which disease affects men and women equally?

A)ulcerative colitis
B)diverticulitis
C)Crohn's disease
D)proctitis

Question 6

Which drug is used to control diarrhea caused by severe IBS and is available only from health care providers who participate in a special prescribing program?

A)infliximab
B)Lomotil
C)alosetron
D)tegaserod

Question 7

Which of the following diseases is treated by administering serotonin receptor antagonists (5-HT₃ and 5-HT₄),antidiarrheals,laxatives,fiber supplements,and anticholinergics?

A)ulcerative colitis
B)irritable bowel syndrome
C)Crohn's disease
D)all of the above

Question 8

MATCHING
Match the following trade and generic drug names.
a.Imodium
b.Remicade
c.Asacol
d.Zelnorm
e.Fibercon
loperamide

Question 9

MATCHING
Match the following trade and generic drug names.
a.Imodium
b.Remicade
c.Asacol
d.Zelnorm
e.Fibercon
infliximab

Question 10

The only FDA-approved anticholinergic drugs used in the treatment of irritable bowel syndrome when diarrhea is the primary symptom are _____.

A)atropine and dicyclomine
B)atropine and cholinesterase
C)dicyclomine and belladonna
D)doxycycline and dicyclomine

Question 11

Which diseases are conditions that are linked to inflammation of gastrointestinal tract?

A)irritable bowel syndrome
B)ulcerative colitis
C)Crohn's disease
D)all of the above

Question 12

Patients who have Crohn's disease may develop _____,which form when an ulcer tunnels from the site of origin to surrounding tissues.

A)ulcers
B)fistulas
C)diverticuli
D)none of the above

Question 13

An immunomodulator that has been approved for the treatment of Crohn's disease is _____.

A)infliximab
B)methotrexate
C)Lomotil
D)dexamethasone

Question 14

What are three common symptoms of irritable bowel syndrome,ulcerative colitis,and Crohn's disease?

A)bloating,constipation,cramping
B)abdominal pain,diarrhea,cramping
C)rectal bleeding,bloating,diarrhea
D)cramping,abdominal pain,bloating

Question 15

The laxatives of choice for treating the symptoms of irritable bowel syndrome are _____.

A)bulk-forming laxatives
B)fiber supplements
C)bile acid sequestrants
D)a and b

Question 16

MATCHING
Match the following trade and generic drug names.
a.Imodium
b.Remicade
c.Asacol
d.Zelnorm
e.Fibercon
polycarbophil

Question 17

Which of the following is not an opioid antidiarrheal administered to control watery and frequent stools and prescribed for the treatment of diarrhea?

A)difenoxin
B)diphenoxylate
C)loperamide
D)dicyclomine

Question 18

MATCHING
Match the following trade and generic drug names.
a.Imodium
b.Remicade
c.Asacol
d.Zelnorm
e.Fibercon
tegaserod

Question 19

MATCHING
Match the following trade and generic drug names.
a.Imodium
b.Remicade
c.Asacol
d.Zelnorm
e.Fibercon
mesalamine