An Older Adult Client Brought to the Emergency Department for Bloody

An older adult client brought to the emergency department for bloody stools has been taking warfarin (Coumadin) post stroke.Initial diagnostic lab work reveals warfarin to be within therapeutic range.The daughter asks why the client has bloody stools if the lab work is normal.Which responses by the nurse are appropriate?
Select all that apply.

A) Liver function declines during the aging process."
B) Decreased liver function results in decreased plasma proteins."
C) Decreased plasma proteins result in more free drug circulating."
D) Decreased plasma proteins lead to more binding sites,resulting in lower concentrations of drugs such as this one."
E) Higher levels of this drug are able to enter the blood-brain barrier,resulting in the toxic effects of bleeding."