Mutations in the cardiac ryanodine receptor have been associated with cardiac arrhythmias.Specifically,a mutation in the cardiac ryanodine receptor that increases Ca⁺⁺ efflux from the SR promotes the development of delayed afterdepolarizations by:

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The mutation in the cardiac ryanodine receptor that increases Ca⁺⁺ efflux from the SR promotes the development of delayed afterdepolarizations by increasing Ca⁺⁺ efflux through the Na⁺-Ca⁺⁺ antiporter. This leads to an increase in intracellular Ca⁺⁺ concentrations, which can trigger delayed afterdepolarizations.

Mutations in the Cardiac Ryanodine Receptor Have Been Associated with Cardiac