A Typical Flow of Information in a Signal Transduction Pathway $\rightarrow$

A typical flow of information in a signal transduction pathway would be which of the following?

A) Receptor $\rightarrow$ G protein $\rightarrow$ second messenger $\rightarrow$ biological response
B) Hormone $\rightarrow$ second messenger $\rightarrow$ G protein-coupled receptor (GPCR) $\rightarrow$ biological response
C) Hormone $\rightarrow$ second messenger $\rightarrow$ GPCR
D) Hormone $\rightarrow$ receptor $\rightarrow$ second messenger $\rightarrow$ GPCR $\rightarrow$ biological response
E) GPCR $\rightarrow$ second messenger $\rightarrow$ biological response