With Regard to Levodopa Administration,"end-Of-Dose Akinesia" Describes the Phenomenon Where

With regard to levodopa administration,"end-of-dose akinesia" describes the phenomenon where:

A) a patient experiences hallucinations and other psychotropic effects.
B) drug effects follow an on-off pattern throughout the day.
C) levodopa seems to become less effective when it is administered for prolonged periods (3 to 4 years) .
D) the effectiveness of levodopa seems to wear off prior to the next dose.
E) none of the above