The "classical pathway" for activation of the complement cascade requires

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The "classical pathway" for activation of the complement cascade requires antibodies. Specifically, when antibodies bind to an antigen, they can serve as a signal for the complement system to activate and begin attacking the pathogen. This pathway is called the "classical pathway" because it was the first complement pathway to be discovered and because it requires the involvement of antibodies, which were traditionally considered part of the adaptive immune system.

The "Classical Pathway" for Activation of the Complement Cascade Requires