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Chemistry
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Organic Chemistry Study Set 15
Quiz 26: Biomolecules: Amino Acids,peptides,and Proteins
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Question 1
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.Show how leucine might be synthesized using the Knowles enantioselective synthesis.
Question 2
Multiple Choice
Exhibit 26-2 MATCH a structure from the list below to each of the following terms.Place the letter of the structure in the blank to the left of the term which it describes. -_____ an amino acid in its zwitterionic form.
Question 3
Multiple Choice
Exhibit 26-2 MATCH a structure from the list below to each of the following terms.Place the letter of the structure in the blank to the left of the term which it describes. -_____ a carboxyl-protected amino acid.
Question 4
Essay
Exhibit 26-4 Refer to the data below to answer the following question(s): Porcine dynorphin is a neuropeptide having 17 amino acid residues.Its structure is shown below. Tyr−Gly−Gly−Phe−Leu−Arg−Arg−Ile−Arg−Pro−Lys−Leu−Lys−Trp−Asp−Asn−Gln -Refer to Exhibit 26-4.Leu
5
-enkephalin is a pentapeptide contained as the N-terminal sequence of dynorphin.Write the structure of Leu
5
-enkephalin using both the three letter and one letter abbreviations for the amino acids.
Question 5
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.Draw the structure of the predominant form of leucine at pH = 1.50.
Question 6
Multiple Choice
Exhibit 26-2 MATCH a structure from the list below to each of the following terms.Place the letter of the structure in the blank to the left of the term which it describes. -_____ an octapeptide with a C-terminal valine.
Question 7
Multiple Choice
Exhibit 26-2 MATCH a structure from the list below to each of the following terms.Place the letter of the structure in the blank to the left of the term which it describes. -_____ a polypeptide which gives four fragments on treatment with chymotrypsin.
Question 8
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.Draw the structure of the predominant form of leucine at pH = 10.00.
Question 9
Short Answer
The most acidic amino acid is ____.
Question 10
Multiple Choice
Exhibit 26-2 MATCH a structure from the list below to each of the following terms.Place the letter of the structure in the blank to the left of the term which it describes. -_____ the product of an Edman degradation.
Question 11
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.How many possible stereoisomers of leucine are there?
Question 12
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.Leucine is described as an essential amino acid.What does this mean?
Question 13
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.Draw the condensed structure for leucine,and label all chirality centers with an asterisk.
Question 14
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.Draw a Fischer projection of L-leucine and label the chirality center(s) as R or S.
Question 15
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.Show the alkyl halide you would use to prepare leucine by the amidomalonate method.
Question 16
Essay
Exhibit 26-1 Refer to the data below to answer the following question(s): Leucine is an essential amino acid with the systematic name 2-amino-3-methylpentanoic acid.It has pK
a1
= 2.36 and pK
a2
= 9.60. -Refer to Exhibit 26-1.What is the pI of leucine?
Question 17
Multiple Choice
Exhibit 26-2 MATCH a structure from the list below to each of the following terms.Place the letter of the structure in the blank to the left of the term which it describes. -_____ a peptide coupling reagent.