Drugs enter the bloodstream from the GI tract and then enter the liver via the hepatic portal vein before entering the general circulation.This route allows the liver to metabolize the drugs into less active or inactive metabolites/drugs before they are distributed throughout the body.This effect is known as the:

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This effect is known as the first-pass effect, where drugs pass through the liver and are metabolized before entering the general circulation.

Drugs Enter the Bloodstream from the GI Tract and Then