Compare the two reaction coordinate diagrams below and select the answer that correctly describes their relationship.In each case,the single intermediate is the ES complex.
A)(a)describes a strict "lock and key" model,whereas (b)describes a transition-state complementarity model.
B)The activation energy for the catalyzed reaction is 5 in (a)and is 7 in (b).
C)The activation energy for the uncatalyzed reaction is given by 5 + 6 in (a)and by 7 + 4 in (b).
D)The contribution of binding energy is given by 5 in (a)and by 7 in (b).
E)The ES complex is given by 2 in (a)and 3 in (b).

Question

Compare the two reaction coordinate diagrams below and select the answer that correctly describes their relationship.In each case,the single intermediate is the ES complex. 
A)(a)describes a strict "lock and key" model,whereas (b)describes a transition-state complementarity model. 
B)The activation energy for the catalyzed reaction is 5 in (a)and is 7 in (b). 
C)The activation energy for the uncatalyzed reaction is given by 5 + 6 in (a)and by 7 + 4 in (b). 
D)The contribution of binding energy is given by 5 in (a)and by 7 in (b). 
E)The ES complex is given by 2 in (a)and 3 in (b).

Quizplus · Accepted Answer

The main difference between the two reaction coordinate diagrams is the shape of the energy curve. In diagram (a), the energy curve has a sharp, deep well, indicating a strict "lock and key" model where the substrate fits perfectly into the active site of the enzyme. In contrast, diagram (b) has a broader, shallower energy well and a higher transition state, suggesting a transition-state complementarity model where the enzyme stabilizes the high-energy transition state to facilitate the reaction.

Compare the Two Reaction Coordinate Diagrams Below and Select the Answer