The metabolite that regulates the activity of carnitine acyl transferase I is:

Question

Quizplus · Accepted Answer

Malonyl-CoA is a potent inhibitor of carnitine acyl transferase I, which controls the entry of fatty acids into the mitochondrial matrix for β-oxidation. Therefore, its presence signals an active state of fatty acid synthesis and halts fatty acid degradation. The other choices are not direct regulators of the enzyme. Acetyl-CoA is a substrate for carnitine acyl transferase, but it does not modulate its activity. The role of carnitine-CoA is to transport fatty acids into the mitochondrial matrix, but it does not influence carnitine acyl transferase. NADH and CoA are not involved in the regulation of the enzyme.

The Metabolite That Regulates the Activity of Carnitine Acyl Transferase