Which of the following scenarios may contribute to the hyperphosphorylation of pRb? A)Inactivation of the Ras pathway B)Inactivation of p21^Cip1 C)Activation of p15^INK4B D)Inactivation of NF-κB E)Activation of Smad3/4

Question

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p21^Cip1 is a cyclin-dependent kinase inhibitor that prevents the phosphorylation of pRb. Inactivation of p21^Cip1 would lead to increased activity of cyclin-dependent kinases, resulting in hyperphosphorylation of pRb.

Which of the Following Scenarios May Contribute to the Hyperphosphorylation