Gene amplification can be detected by
A)Observation of homogeneously staining regions using microscopy.
B)Deletion of the arm of a chromosome.
C)Observation of extrachromosomal "double minutes."
D)A and C.
E)None of the above.

Question

Quizplus · Accepted Answer

Observation of homogeneously staining regions (HSRs) and extrachromosomal "double minutes" (DMs) are both indicative of gene amplification, with HSRs being localized amplification on a chromosome and DMs being extrachromosomal circles of DNA carrying amplified genes. Deletion of a chromosome arm is not indicative of gene amplification.

Gene Amplification Can Be Detected by