The transforming abilities of the Bcr-Abl fusion protein are due primarily to the deregulated firing of its tyrosine kinase,which is equivalent to what domain of the normal Abl protein?
A)The SH1 domain
B)The SH2 domain
C)The SH3 domain
D)The DNA binding domain
E)None of the above

Question

Quizplus · Accepted Answer

The SH1 domain is the catalytic domain of the Abl protein, responsible for its tyrosine kinase activity. The Bcr-Abl fusion protein deregulates this domain, leading to uncontrolled cell division and the development of chronic myeloid leukemia (CML). The other domains listed (SH2, SH3, DNA binding) have important functions in Abl signaling but are not directly responsible for the tyrosine kinase activity that drives transformation in CML.

The Transforming Abilities of the Bcr-Abl Fusion Protein Are Due