Individuals Who Have Two Defective Alleles of the AIRE Gene

Individuals who have two defective alleles of the AIRE gene _____.

A) exhibit symptoms of autoimmunity at a young age
B) are unable to activate regulatory T cells
C) exhibit decreased predisposition to autoimmune disease
D) are very effective at inducing anergy of circulating autoreactive B and T cells
E) are more likely to be women of African or Asian origin.