Deficiency in the Production of AIRE Results in _____

Deficiency in the production of AIRE results in _____.(Select all that apply.)

A) normal expression of tissue-specific proteins in the bone marrow and thymus
B) incomplete negative selection of developing T cells
C) the development of autoimmune B-cell and T-cell responses against endocrine glands and other tissues
D) death in infancy
E) the development of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) .