Autoantibody Specificities Are Affected by HLA Class II Polymorphisms

Autoantibody specificities are affected by HLA class II polymorphisms.In the case of systemic lupus erythematosus,indicate which of the following associations between HLA-class II and autoantigens have been observed in these patients.

A) HLA-DR3; nuclear ribonucleoprotein complex
B) HLA-DR5; small cytoplasmic ribonucleoprotein complex
C) HLA-DR2; double-stranded DNA
D) HLA-DR4; single-stranded RNA
E) HLA-DQ8; double-stranded RNA.