The underlying molecular basis for distinguishing blood-group antigens A,B and O is _____ at the erythrocyte surface.

Question

Quizplus · Accepted Answer

The underlying molecular basis for distinguishing blood-group antigens A, B, and O is the differences in the oligosaccharide attached to the lipid ceramide at the erythrocyte surface. The antigenic determinants for blood groups A and B are N-acetylgalactosamine and galactose, respectively, which are added to the H antigen precursor. The H antigen, which is present in individuals with blood group O, lacks these modifications. Therefore, the presence or absence of these terminal sugar residues on the oligosaccharide chain distinguishes blood group antigens A, B, and O.

The Underlying Molecular Basis for Distinguishing Blood-Group Antigens A,B and O