Which of the following exerts its effect by inhibiting the activation of calcineurin by calcium and thereby interferes with nuclear translocation of NFAT? (Select all that apply.)

Question

Quizplus · Accepted Answer

Tacrolimus (FK506) and cyclosporin A are both calcineurin inhibitors that work by inhibiting the activation of calcineurin by calcium, which interferes with the nuclear translocation of NFAT. Mycophenolic acid inhibits inosine monophosphate dehydrogenase, which is involved in de novo synthesis of purines and leads to decreased lymphocyte proliferation. Cyclophosphamide is an alkylating agent that cross-links DNA and leads to cell death. Belatacept is a CTLA-4Ig fusion protein that blocks the co-stimulatory signal required for T cell activation.

Which of the Following Exerts Its Effect by Inhibiting the Activation