As time progresses following an organ transplant,the alloreactive T-cell response shifts from a(n)_____ pathway to a(n)_____ pathway of allorecognition.

Question

Quizplus · Accepted Answer

The direct pathway of allorecognition involves the recognition of donor MHC molecules on the surface of antigen-presenting cells by recipient T cells, leading to their activation and subsequent attack on the graft. The indirect pathway, on the other hand, involves the processing and presentation of donor MHC molecules by recipient antigen-presenting cells, leading to the activation of alloreactive T cells. As time progresses following an organ transplant, the alloreactive T-cell response shifts from the direct pathway to the indirect pathway of allorecognition, which is more reflective of a chronic rejection response.

As Time Progresses Following an Organ Transplant,the Alloreactive T-Cell Response