Bare lymphocyte syndrome leading to a lack of HLA class II molecule expression is due to a defect in _____.

Question

Quizplus · Accepted Answer

Bare lymphocyte syndrome (also called MHC class II deficiency or HLA class II deficiency) is due to a defect in transcriptional regulators that control the expression of Major Histocompatibility Complex (MHC) class II genes. This results in the absence or reduction of MHC class II molecules on the surface of antigen-presenting cells (APCs), leading to impaired immune responses.

Bare Lymphocyte Syndrome Leading to a Lack of HLA Class