A.Deficiencies in antibody production can be due to a variety of underlying genetic defects.Name two immunodeficiency diseases,other than the severe combined immunodeficiencies,in which a defect in antibody production is the cause of the disease,and for which the underlying genetic defect is known.For each disease,say (i)how antibody production is affected,and (ii)what the underlying defect is and why it has this effect.
B.What is the main clinical manifestation of immunodeficiency diseases in which antibody production is defective but cell-mediated immune responses are intact?
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