What would be the outcome if a naive B cell were to bind to pathogen coated with specific antibody made by an effector B cell in a primary immune response using FcγRIIB1,and simultaneously bind to the same pathogen using its B-cell receptor?

Question

Quizplus · Accepted Answer

The binding of a pathogen by a naive B cell through its B-cell receptor (BCR) while simultaneously engaging the FcγRIIB1 receptor with an antibody-coated pathogen sends an inhibitory signal. This interaction effectively prevents the activation of the B cell, thereby inhibiting the production of low-affinity IgM antibodies. This mechanism helps in regulating the immune response, ensuring that B cells with higher affinity receptors are selected for activation and proliferation.

What Would Be the Outcome If a Naive B Cell