Imagine a situation in which an individual who has a latent cytomegalovirus (CMV)infection receives a hematopoietic stem-cell transplant.Which of the following is likely to occur?

Question

Quizplus · Accepted Answer

In a person with a latent CMV infection, the transplant-derived naive T cells would be activated and give rise to memory T cells. These memory T cells would persist and control the viral load. This is because, in an immunocompromised state (as seen in the case of a stem-cell transplant recipient), the new naive T cells would not be inhibited by memory T cells, allowing them to differentiate into effector cells to fight the CMV infection. Over time, some of these effector cells would become memory T cells and persist in the host, providing long-term protection against CMV reactivation. This process is known as de novo T-cell generation.

Imagine a Situation in Which an Individual Who Has a Latent