Reasons complicating the development of vaccines to combat chronic diseases include _____.(Select all that apply.)

Question

Quizplus · Accepted Answer

All of the options listed can contribute to the difficulty in developing vaccines for chronic diseases. Pathogens can evade the host's immune system, which makes it more difficult for the immune system to identify and eliminate the pathogen. Polymorphic diversity in MHC molecules makes it difficult to develop vaccines that can target all variants. Inappropriate immune responses can also occur, which can cause side effects and may not effectively eliminate the pathogen. The survival of the pathogen for long periods inside the host also makes vaccine development more challenging, as the pathogen is able to continue replicating and causing damage. Finally, high mutation rates in the pathogen can result in rapid changes in the pathogen's structure, making it difficult to create a vaccine that is effective for long periods of time.

Reasons Complicating the Development of Vaccines to Combat Chronic Diseases