To mount the most effective antibody response that results in the synthesis of high-affinity antibodies,which of the following must occur? (Select all that apply.)

Question

Quizplus · Accepted Answer

Isotype switching and affinity maturation are both essential for the synthesis of high-affinity antibodies. Recognition of thymus-independent antigens (A) may result in a weak antibody response, while increased expression of TLR9 by B cells (C) would enhance their response to DNA-containing antigens but not necessarily result in high-affinity antibodies. Decreased expression of CD40 by B cells (E) would inhibit their activation and differentiation, but alone would not lead to the synthesis of high-affinity antibodies.

To Mount the Most Effective Antibody Response That Results in the Synthesis