A Primary Focus of Clonal Expansion Is Best Described as _____

A primary focus of clonal expansion is best described as _____.

A) the location in the B-cell zone where conjugate pairs of B and T cells undergo cellular proliferation,isotype switching,and somatic hypermutation
B) the location in the medullary cords where conjugate pairs of B cells and T cells undergo cellular proliferation and IgM is secreted
C) the dark zone of the germinal center where centroblasts divide and pack closely together
D) the initial wave of B-cell proliferation induced by T-independent antigens.