Some types of B-cell tumor have been treated with rituximab,an anti-CD20 monoclonal antibody,which exerts its effect through a mechanism known as ______ involving the participation of NK cells.

Question

Quizplus · Accepted Answer

Antibody-dependent cell-mediated cytotoxicity (ADCC) is the mechanism through which rituximab exerts its effect on B-cell tumors. This involves the binding of rituximab to CD20 on target B-cells, followed by recognition and effector cell-mediated killing of the target cells, mainly through the participation of natural killer (NK) cells.

Some Types of B-Cell Tumor Have Been Treated with Rituximab,an