The enzyme that generates diacylglycerol (DAG)and inositol trisphosphate (IP₃)from phosphatidylinositol bisphosphate (PIP₂)is _____.

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Quizplus · Accepted Answer

The enzyme that generates diacylglycerol (DAG) and inositol trisphosphate (IP3) from phosphatidylinositol bisphosphate (PIP2) is phospholipase C-γ (PLC-γ). PLC-γ is activated by various signaling pathways, including the activation of receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCRs). Activation of PLC-γ results in the hydrolysis of PIP2 to generate DAG and IP3, which activate downstream signaling pathways such as the protein kinase C (PKC) pathway and the release of Ca2+ from intracellular stores, respectively. PKC-θ is a downstream effector of DAG and is involved in various cellular processes such as immune responses and glucose metabolism, but it is not the enzyme that generates DAG and IP3 from PIP2. Calcineurin, ZAP-70, and Lck are not involved in this pathway.

The Enzyme That Generates Diacylglycerol (DAG)and Inositol Trisphosphate (IP3)from Phosphatidylinositol

The Enzyme That Generates Diacylglycerol (DAG)and Inositol Trisphosphate (IP₃)from Phosphatidylinositol