The function of negative selection of thymocytes in the thymus is to eliminate

Question

Quizplus · Accepted Answer

The function of negative selection is to eliminate autoreactive thymocytes, which are T cells that recognize and attack the body's own tissues. This is an important mechanism for preventing autoimmune diseases. Single-positive and double-positive thymocytes are not eliminated during negative selection. Alloreactive T cells are those that recognize and attack foreign tissues with different MHC molecules, but they are not eliminated during negative selection. Apoptotic thymocytes refer to dying or dead thymocytes and are not relevant to negative selection.

The Function of Negative Selection of Thymocytes in the Thymus