A defect in which of the following proteins blocks B-cell development at the pre-B-cell stage,resulting in almost no circulating antibodies in individuals with this defect?

Question

Quizplus · Accepted Answer

Bruton's tyrosine kinase (Btk) is responsible for signaling in B-cell development at the pre-B-cell stage. Defects in Btk result in X-linked agammaglobulinemia, where there is a lack of mature B cells and almost no circulating antibodies. IL-7 receptor, TdT, Pax-5, and CD19 are all important in B-cell development but do not have the same level of impact on pre-B-cell development as Btk.

A Defect in Which of the Following Proteins Blocks B-Cell