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Which of the Following Best Describes the Function of Tapasin

Question 12

Multiple Choice

Which of the following best describes the function of tapasin?


A) Tapasin is an antagonist of HLA-DM and causes more significant increases in MHC class I than MHC class II on the cell surface.
B) Tapasin is a lectin that binds to sugar residues on MHC class I molecules,T-cell receptors,and immunoglobulins and retains them in the ER until their subunits have adopted the correct conformation.
C) Tapasin is a thiol-reductase that protects the disulfide bonds of MHC class I molecules.
D) Tapasin participates in peptide editing by trimming the amino terminus of peptides to ensure that the fit between peptide and MHC class II molecules is appropriate.
E) Tapasin is a bridging protein that binds to both TAP and MHC class I molecules and facilitates the selection of peptides that bind tightly to MHC class I molecules.

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