The mechanisms contributing to peptide editing include which of the following? (Select all that apply.)

Question

Quizplus · Accepted Answer

- A) The endoplasmic reticulum aminopeptidase (ERAP) trims peptides in the ER to help them fit better into MHC class I molecules, a process that can be considered part of peptide editing.- C) Tapasin assists in the loading of peptides onto MHC class I molecules by stabilizing the MHC class I molecule until a suitable peptide is found, which is a form of peptide editing.- D) The recycling of an MHC class I heterodimer if the peptide falls out is a mechanism to ensure that only stable peptide-MHC class I complexes are presented on the cell surface, which is another form of peptide editing.

The Mechanisms Contributing to Peptide Editing Include Which of the Following