The immunological consequence of severe combined immunodeficiency disease (SCID)caused by a genetic defect in either RAG-1 or RAG-2 genes is

Question

Quizplus · Accepted Answer

RAG-1 and RAG-2 genes are important for the process of somatic recombination, which occurs in both T-cell receptor and immunoglobulin gene loci. Therefore, a genetic defect in either RAG-1 or RAG-2 genes would result in a lack of somatic recombination in both T-cell receptor and immunoglobulin gene loci, leading to severe combined immunodeficiency disease (SCID).

The Immunological Consequence of Severe Combined Immunodeficiency Disease (SCID)caused by a Genetic