In Contrast with Leader Peptides and the C Regions,the V

In contrast with leader peptides and the C regions,the V regions in immunoglobulin heavy-chain genes

A) encode hydrophobic amino acids that anchor the immunoglobulin chains to B-cell membranes
B) comprise the smallest number of gene segments in the human immunoglobulin loci
C) are composed of V,D,and J gene segments that must undergo gene rearrangement to generate a transcribable exon
D) do not undergo somatic hypermutation
E) are not subject to allelic exclusion.