Junctional diversity during gene rearrangement results from the addition of

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Junctional diversity refers to the variation in nucleotide sequences at the junctions between gene segments that occur during the process of V(D)J recombination. P and N nucleotides are the type of nucleotides that are added during this process and contribute to junctional diversity. Switch region nucleotides (A) are involved in isotype switching, V, D, and J nucleotides (C) are the gene segments that recombine to form the final gene sequence, and recombination signal sequences (D) are the sequences that flank the gene segments and are necessary for recombination to occur. Mutations in complementarity-determining regions (E) can also contribute to diversity but are not specific to junctional diversity during gene rearrangement.

Junctional Diversity During Gene Rearrangement Results from the Addition of