In Aging Patients,distribution of Drugs May Be Lessened Because of a Decline

In aging patients,distribution of drugs may be lessened because of a decline in total body water and lean body mass,warranting the use of decreased dosing.Which drugs are distributed into body water or lean muscle mass and may lead to increased effects and possible toxicity for the aging patient? (Select all that apply.)

A) Digoxin (Lanoxin)
B) Gentamicin (Garamycin)
C) Meperidine (Demerol)
D) Acetaminophen (Tylenol)
E) Ibuprofen (Motrin)