How does the development of protein aggregates in Huntington's disease bring about dementia in patients?

Question

Quizplus · Accepted Answer

In Huntington's disease, protein aggregates develop in the caudate region of the brain, which is responsible for motor control and cognitive processing. As the protein aggregates accumulate, they disrupt the neuronal connection between the caudate region and the frontal lobe, which results in the development of dementia in patients. The disruption of this connection leads to progressive cognitive decline, including memory loss, difficulty in processing information, and inability to plan and organize.

How Does the Development of Protein Aggregates in Huntington's Disease