Kearns- Sayre syndrome KSS results in progressive loss of vision and hearing,as well as heart defects.What is the genetic basis for this disease?
A)ATP builds up and runs the electron transport chain backwards.
B)Reactive oxygen species mutate DNA.
C)Ageing shortens the telomeres of the mitochondrial DNA.
D)Too much sunlight damages mtDNA.
E)Deletions occur in mtDNA,and the proportion of defective mtDNAs increases as the severity of the symptoms increases.

Question

Quizplus · Accepted Answer

Kearns-Sayre syndrome is caused by deletions in mitochondrial DNA (mtDNA), which result in a decrease in the overall amount of mtDNA and an increase in the proportion of defective mtDNAs. This leads to impaired oxidative phosphorylation and the symptoms of the disease. The other choices listed are not related to the genetic basis of this disease.

Kearns- Sayre Syndrome KSS Results in Progressive Loss of Vision