A client will begin antibacterial drug therapy with chloramphenicol (Chloromycetin).The nurse places highest priority on assessing the results of which of the following baseline laboratory studies?

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The most important laboratory study to assess before starting chloramphenicol therapy is a complete blood count (CBC) because chloramphenicol is associated with the rare but potentially fatal side effect of aplastic anemia. This condition involves a reduction in the production of red blood cells, white blood cells, and platelets, and can occur within the first few days of therapy or even weeks to months afterward. Therefore, it is important to assess the patient's blood counts at baseline and periodically during therapy to detect any signs of bone marrow suppression. Serum electrolytes may be assessed to monitor for metabolic abnormalities or electrolyte imbalances, serum glucose may be assessed to monitor for hyperglycemia or hypoglycemia, and activated partial thromboplastin time may be assessed to monitor coagulation status. However, these laboratory studies are not as crucial as the CBC for assessing the risk of aplastic anemia.

A Client Will Begin Antibacterial Drug Therapy with Chloramphenicol (Chloromycetin)