The hormone secretin is released by endocrine cells in the duodenal mucosa in response to
A) distention of the stomach
B) carbohydrate in the duodenum
C) acid in the duodenum
D) gastrin secreted by the pyloric gland area of the stomach
E) none of these

Question

Quizplus · Accepted Answer

Secretin is released in response to acid in the duodenum. When acidic chyme enters the duodenum from the stomach, it triggers the release of secretin by endocrine cells in the duodenal mucosa. Secretin then enters the bloodstream and travels to the pancreas, where it stimulates the release of bicarbonate ions to neutralize the acid, and to the liver, where it stimulates the release of bile. Thus, secretin helps maintain a proper pH in the small intestine for optimal digestive enzyme function.

The Hormone Secretin Is Released by Endocrine Cells in the Duodenal