A technologist is reviewing a lymph node biopsy slide and notices a prominent lymphocytosis as well as the presence of a few tumor cells with the following characteristics: large, multilobated nucleus with delicate nuclear membranes; finely granular chromatin; and small, indistinct nucleoli. Based on this information, what is the likely diagnosis?

Question

Quizplus · Accepted Answer

The description of tumor cells with a large, multilobated nucleus, finely granular chromatin, and small, indistinct nucleoli, along with a background of prominent lymphocytosis, is characteristic of Hodgkin lymphoma, specifically the lymphocyte-rich subtype. This subtype is known for its relative abundance of lymphocytes and the presence of Reed-Sternberg cells, which are large cells with a multilobated nucleus and the described nuclear features.

A Technologist Is Reviewing a Lymph Node Biopsy Slide and Notices