A physician is working up a patient. Based on physical examination, history, and initial screening tests, the physician suspects anaplastic large cell lymphoma (ALCL), but still needs to rule out classical Hodgkin lymophoma (HL). Which of the following test results would confirm ALCL?

Question

Quizplus · Accepted Answer

ALCL is typically characterized by the expression of CD30 on tumor cells, often with a lack of other T-cell markers such as CD3. However, the presence of CD3 along with CD30 can still indicate ALCL, distinguishing it from classical Hodgkin lymphoma, which usually shows CD15 and CD30 positivity.

A Physician Is Working Up a Patient