A technologist is reviewing a blood smear and notices 35% lymphocytes with azurophilic granules and nuclei with mature clumped chromatin. These cells are typical of those found in:

Question

Quizplus · Accepted Answer

The description of lymphocytes with azurophilic granules and nuclei with mature clumped chromatin points towards large granular lymphocyte leukemia, which is characterized by a proliferation of large granular lymphocytes. Hairy cell leukemia and chronic prolymphocytic leukemia are not typically associated with this specific cell appearance. Sézary syndrome is a variant of cutaneous T-cell lymphoma and would not typically present with lymphocytes with azurophilic granules.

A Technologist Is Reviewing a Blood Smear and Notices 35