Which of the following combinations leads to tumor formation?
A) Activation of oncogenes and suppression of proto-oncogenes
B) Activation of proto-oncogenes with concurrent suppression of oncogenes
C) Activation of oncogenes and suppression of tumor-suppressor genes
D) Activation of tumor suppressor genes and suppression of proto-oncogenes

Question

Quizplus · Accepted Answer

Tumor formation occurs when there is an activation of oncogenes, which are genes that promote cell division, and suppression of tumor-suppressor genes, which normally prevent uncontrolled cell growth. Activation of proto-oncogenes is not enough to cause tumor formation, as they only promote cell division in a controlled manner, and suppression of oncogenes would not lead to tumor formation as they do not normally restrict cell growth. Activation of tumor suppressor genes and suppression of proto-oncogenes would also not lead to tumor formation as it would prevent uncontrolled cell growth rather than promoting it.

Which of the Following Combinations Leads to Tumor Formation