Which of the following cytochemical stains can help differentiate AML from ALL?
A) PAS stain
B) LAP stain
C) MPO stain
D) NSE stain

Question

Quizplus · Accepted Answer

MPO (myeloperoxidase) stain is a specific stain for myeloid cells and can help differentiate AML (acute myeloid leukemia) from ALL (acute lymphoblastic leukemia). AML cells are positive for MPO, while ALL cells are negative. PAS (Periodic Acid-Schiff) stain is used to detect glycogen and is not specific for any type of leukemia. LAP (leukocyte alkaline phosphatase) stain is used to evaluate neutrophil function, but does not help differentiate between AML and ALL. NSE (neuron-specific enolase) stain is used to detect neuroendocrine tumors, and is not helpful in distinguishing between AML and ALL.

Which of the Following Cytochemical Stains Can Help Differentiate AML