A healthy individual has his blood drawn as a part of a routine physical. The laboratician performing the differential notes a neutrophil with a nucleus that appears dumbbell shaped. After scanning the entire slide, it appears that the vast majority of neutrophils have the same, bi-lobed nuclei with highly clumped nuclear chromatin. All other leukocytes appear normal. The conclusion from this is that the patient has:

Question

Quizplus · Accepted Answer

The bi-lobed nuclei with highly clumped nuclear chromatin seen in the majority of the neutrophils is characteristic of the Pelger-Huët anomaly, which is a benign inherited condition that affects the morphology of neutrophils. May-Hegglin anomaly is characterized by giant platelets and inclusion bodies in neutrophils. Hypersegmented neutrophils are seen in megaloblastic anemia. Alder-Reilly anomaly is characterized by large, dark-staining granules in leukocytes.

A Healthy Individual Has His Blood Drawn as a Part