A sample has the following test results: hemoglobin 9 g/dL, autohemolysis increased after 48 hours, and increased hemolysis observed with the Ham test and sucrose hemolysis test. Based on these findings, what is the patient most likely suffering from?
A) HS
B) HE
C) PNH
D) PCH

Question

Quizplus · Accepted Answer

The patient is likely suffering from paroxysmal nocturnal hemoglobinuria (PNH), as evidenced by the increased autohemolysis, and positive results on both the Ham test and sucrose hemolysis test. Hemolytic anemia is a hallmark of PNH, and although the hemoglobin concentration is low, it is not specific to this condition. HS (hereditary spherocytosis) and HE (hereditary elliptocytosis) are genetic disorders of the red blood cell membrane, but the findings in this case are not consistent with these conditions. PCH (paroxysmal cold hemoglobinuria) is a rare autoimmune disorder characterized by hemolysis that occurs in response to cold temperatures, and is also not likely in this case based on the presented findings.

A Sample Has the Following Test Results: Hemoglobin 9 G/dL